T cell receptor (TCR) signaling

Author: V. Dimov, M.D., Fellow, Creighton University Division of Allergy & Immunology
Reviewer: S. Randhawa, M.D., Fellow, LSU (Shreveport) Department of Allergy & Immunology


This video describes the cellular signaling that takes place with the T cell receptor. This video is from: Janeway's Immunobiology, 7th Edition Murphy, Travers, & Walport. Source: Garland Science.


T-cell receptor complex with TCR-α and TCR-β chains. Image source: Wikipedia.

The first event following the TCR ligation (binding) is the activation of Src kinases - autoinhibitory loop.

CD45 phosphorylation in TCR signaling is of early and key importance. CD45 and ZAP70 defects cause SCID.

ZAP70

ZAP 70 binds to the Zeta chain (CD247) of the T-cell receptor.

Z
ZAP-70
Zeta-chain-associated protein kinase 70 (70 is the molecular weight in kDa)

ZAP70 deficiency is a form of SCID (T-/B+/NK+), one of the few SCID forms with palpable LN.


TCR-APC Interaction. This video describes the process by which an antigen presenting cell interacts with a T cell. This video is from: Janeway's Immunobiology, 7th Edition Murphy, Travers, & Walport. Source: Garland Science.


Lipid rafts are specialized regions of the cell membrane that are enriched for particular lipids and cholesterol, and consequently more rigid than the rest of the membrane. This video is from: Janeway's Immunobiology, 7th Edition Murphy, Travers, & Walport. Source: Garland Science.


Immunological Synapse. This video describes the structure and function of an immunological synapse, the zone of contact between a T cell and an antigen presenting cell. This video is from: Janeway's Immunobiology, 7th Edition Murphy, Travers, & Walport. Source: Garland Science.

Published: 06/28/2008
Updated: 06/17/2009