Mnemonics: Drug Hypersensitivity

Author: V. Dimov, M.D.
Reviewer: S. Randhawa, M.D.

Classification of adverse reactions to drugs: SOAP III

Side effect
Overdose
Allergy
Pseudoallergy

Interaction
Intolerance
Idiosyncrasy

Rule of 10s in ADR

10% of patients develop ADR
10% are due to allergy
10% lead to anaphylaxis
10 % lead to death

Manifestations of beta-lactams hypersensitivity: MAUS

Maculopapular exanthema, 19%
Anaphylaxis without shock, 19%
Urticaria, 36%
Shock, anaphylactic shock, 17%

References: Clinical presentation and time course in hypersensitivity reactions to β-lactams. Allergy, 2007.

Samter's triad include asthma, aspirin sensitivity, and nasal/ethmoidal polyposis:

ASPirin
Asthma
Sensitivity to aspirin
Polyps

T
Toxic epidermal necrosis (TEN)
Thirty percent of the skin (SJS less than 10%)
"Terrible" prognosis

Management of adverse drug reactions: PAD

Premedication with antihistamines and steroids
Avoidance
Desensitization

Multiple choice questions

Chapter 57: Drug Allergy. Allergy and Immunology Review Corner: Chapter 57 of Pediatric Allergy: Principles & Practices, edited by Donald Y.M. Leung, et al.

Published: 01/24/2008
Updated: 07/24/2009